I-CORE - Israeli Centers Of Research Excellence I-CORE - Israeli Centers Of Research Excellence I-CORE - Israeli Centers Of Research Excellence Israeli Centers Of Research Excellence

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Gene Regulation in Complex Human Disease I-CORE Conference

Gene Regulation in Complex Human Disease I-CORE Conference

 

The Gene Regulation in Complex Human Disease I-CORE held a conference for its members on April 3, 2012 at Tel Aviv University. I-CORE faculty, students, post-docs and researchers gathered together to exchange scientific ideas and hear some members describe their latest findings in the study of complex human disease.

 

The conference was opened by Prof. Karen Avraham of Tel Aviv University, recent recipient of the Teva Prize, followed by the I-CORE scientific director, Prof. Chaim Cedar, recent recipient of the Rothschild Prize, from the Hebrew University of Jerusalem. Prof. Cedar described the crucial importance of studying normal cellular processes in order to understand pathology, diseases and medicine. The goal of the “Systems-Level Analysis of the Molecular Basis for Human Diseases: From Genomics to Personalized Therapy” I-CORE is to bring this idea to fruition by combining the excellence of researchers in universities and hospitals. Now the goal is to “go ahead and get results and make things move dynamically; for this we are relying on all of you.” Prof. Cedar went on to describe a basic biological process, methylation, which has important implications for disease, in particular cancer.

 

The future Metabolomics Core was introduced by Prof. Shulamit Michaeli, one of the I-CORE Board Members, followed by a description of the Proteomics Core by new faculty member Dr. Tamar Geiger. The science presentation that followed was spectacular, from Dr. Noam Shomron’s description of regulation by microRNAs in infectious diseases, with an emphasis on HIV pathogen detection; to Dr. Ela Elyada (Prof. Yinon Ben-Neriah’s group) on senescence-associated inflammation in colon cancer and Dr. Agnes Klochendler (Prof. Yuval Dor’s lab) described a mouse designed to allow identification of replicating cells in diabetes research. Shoshana Naiman from Haim Cohen’s group described the longer life span of SIRT6 male mice. Dr. Erez Levanon (recent winner of the Krill Prize) described how we need to take RNA editing into account when considering the evolution of retroelements. Computional modelling was performed by Prof. Hanah Margalit in order to find drugs that interfere with the microRNA machinery. Daphna Nachmani from Prof. Ofer Mandelboim’s lab told the audience how innate immunity is inhibited and activated by cellular and viral microRNAs, and Yaron Orenstein from Prof. Ron Shamir’s group defined algorithms and software tools they developed for understanding gene regulation.

 

The conference was wrapped up by Dan Dominissini from Prof. Gidi Rechavi’s lab when he described RNA modifications and their link to disease. Altogether, the work emphasized the biological mechanisms taking place that underlie human disease. New investigators Dr. Irit Gat-Vicks, Dr. Carmit Levy, and Dr. Amit Tzur were also present with their new lab members.

 

More information can be viewed at: http://www.icore-human-disease.org/ 

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  1. From right to left: Dr. Yuval Dor, Dr. Haim Cohen, Prof. Karen Avraham, Dr. Noam Shomron, Prof. Batsheva Kerem, Prof. Howard Cedar, Dr. Carmit Levy, Prof. Yossi Shiloh, Dr. Amit Tzur, Dr. Tamar Geiger, Prof. Eytan Ruppin

    From right to left: Dr. Yuval Dor, Dr. Haim Cohen, Prof. Karen Avraham, Dr. Noam Shomron, Prof. Batsheva Kerem, Prof. Howard Cedar, Dr. Carmit Levy, Prof. Yossi Shiloh, Dr. Amit Tzur, Dr. Tamar Geiger, Prof. Eytan Ruppin